Association of vitamin D deficiency and inflammatory cytokines with the clinicopathological features of breast cancer in female Saudi patients

Breast cancer is the leading cause of cancer-related death among women in Saudi Arabia. Many studies have suggested a strong correlation between vitamin D and multiple types cancer. This study included 100 female patients with early or locally advanced breast Patients were recruited from King Faisal Hospital Taif City, Arabia, January 2020 to September 2020. We aimed association serum D, calcium, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α) chemerin progression. The control group consisted healthy individuals. Serum levels IL-6, TNF-α measured all participants. Vitamin was significantly decreased high-grade tumours ( p < 0.0001), obesity = 0.013), negative oestrogen receptors progesterone 0.0001) positive HER2 0.0001). also large axillary lymph node involvement advanced-stage cancers Moreover, higher associated presence cancer, particularly its stages. deficiency elevated TNF- α adverse clinicopathological features inflammatory cytokines (IL-6, chemerin) patients.